Steve Callaghan, showrunner, announced at Comic-Con that the new season will feature an episode that kills off a main mharacter.When pressed for a more specific anower, Callaghan said it could be any six main characters. He didn't say if they will be permanently dead or if it'll be another "dream" episode like they did a few years ago when Stewie finally killed Lois.

Here's a clip from panel at last weekend's Comic-Con:

So, Family Guy fans--who will get the axe?  Meg, Peter, Stewie, Lois, Brian, or Chris.